ASTR-US ASTRA AWARDED VADR CONTRACT BY NASA JANUARY 27, 2022 Alameda, CA. January 27, 2022. Astra Space, Inc. (“Astra”) (Nasdaq: ASTR), today announced the award of the Venture-Class Acquisition of Dedicated and Rideshare (VADR) Launch Services Indefinite Delivery/Indefinite Quantity (IDIQ) contract from the National Aeronautics and Space Administration (NASA) for future task orders, which have not yet been issued. This contract has a five-year ordering period with a…

ZYNE Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants 2022 Richard B van Breemen et al. J Nat Prod. https://pubmed.ncbi.nlm.nih.gov/35007072/ As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19. Affinity selection-mass spectrometry was used for the discovery of botanical ligands to the SARS-CoV-2 spike protein. Cannabinoid acids from hemp (Cannabis sativa) were found to be allosteric as well as orthosteric ligands with micromolar affinity for the spike protein. In follow-up virus neutralization assays, cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by a pseudovirus expressing the SARS-CoV-2 spike protein and prevented entry of live SARS-CoV-2 into cells. Importantly, cannabigerolic acid and cannabidiolic acid were equally effective against the SARS-CoV-2 alpha variant B.1.1.7 and the beta variant B.1.351. Orally bioavailable and with a long history of safe human use, these cannabinoids, isolated or in hemp extracts, have the potential to prevent as well as treat infection by SARS-CoV-2.

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