$APLT Доброй ночи! On January 27, 2022, Charles Silberstein notified Applied Therapeutics, Inc. (the “Company”) of his intention to resign as Chief Financial Officer and Principal Financial Officer of the Company, effective January 28, 2022, in order to pursue another opportunity. Mr. Silberstein's resignation does not result from any disagreement with the Company on any matter relating to the Company’s operations, policies or practices. The Company has appointed Chids Mahadevan, Vice President Finance and Principal Accounting Officer, as the interim Principal Financial Officer. Mr. Mahadevan will serve as the interim Principal Financial Officer while the Company conducts its search for a new Chief Financial Officer.